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Spravato treatment centres in Italy — full list (22 centres, updated July 2026)

Italy has 22 registry-verified Spravato (esketamine) treatment centres — in Bari (4), Brindisi (2), Acquaviva delle Fonti, Altamura and 14 more cities. Every centre is listed below with its access route, reimbursement note and the source it was verified against. Europe-wide picture: certified Spravato centres in Europe.

Certified centers administering esketamine nasal spray for treatment-resistant depression under medical supervision, usually within reimbursement programs.

Designated-centers model

All typesSpravato®Ketamine / KAPClinical trialsPAT
Spravato®Registry-verified

AOU Policlinico Consorziale di Bari (U.O.: Neurologia Universitaria Amaducci; Neurologia Universitaria Puca; Neurologia Ospedaliera; Psichiatria Universitaria)

Bari, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Ente Ecclesiastico F. Miulli (U.O.: Neurologia)

Acquaviva delle Fonti, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Di Venere (U.O.: Neurologia)

Bari, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. della Murgia - Altamura (U.O.: Neurologia; Neurologia 2; Psichiatria; Servizio di Psichiatria)

Altamura, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

Ospedale Monopoli-Fasano (ex P.O. San Giacomo) (U.O.: Neurologia)

Monopoli, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. San Paolo - Bari (U.O.: Neurologia; Epilessia ed EEG Eta evolutiva)

Bari, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

SPDC P.O. San Paolo - Bari (U.O.: Servizio di Psichiatria)

Bari, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

SPDC P.O. Putignano (U.O.: Servizio di Psichiatria)

Putignano, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. A. Perrino - Brindisi (U.O.: Neurologia; Psichiatria)

Brindisi, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

IRCCS Eugenio Medea (Ostuni) (U.O.: Neuroriabilitazione)

Brindisi, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Bonomo - Andria (U.O.: Neurologia)

Andria, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Mons. R. Dimiccoli - Barletta (U.O.: Neurologia; Psichiatria)

Barletta, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Vittorio Emanuele II - Bisceglie (U.O.: Psichiatria)

Bisceglie, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

OO.RR. Foggia (Policlinico Riuniti) (U.O.: Neurologia Universitaria; Neurologia Ospedaliera; Servizio Psichiatria a Direzione Univ.; Psichiatria a Direzione Univ.)

Foggia, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. San Camillo de Lellis - Manfredonia (U.O.: Psichiatria)

Manfredonia, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Teresa Masselli-Mascia - San Severo (U.O.: Psichiatria)

San Severo, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Vito Fazzi - Lecce (U.O.: Neurologia; Psichiatria)

Lecce, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Ferrari - Casarano (U.O.: Neurologia; Psichiatria)

Casarano, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. San Giuseppe da Copertino - Copertino (U.O.: Servizio Neurologia)

Copertino, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Santa Caterina Novella - Galatina (U.O.: Psichiatria)

Galatina, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. Veris delli Ponti - Scorrano (U.O.: Psichiatria)

Scorrano, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →
Spravato®Registry-verified

P.O. SS. Annunziata / Moscati - Taranto (U.O.: Neurologia; Psichiatria)

Taranto, Italy
Esketamine nasal spray (Spravato®)
Eligibility check →

Costs and coverage in Italy

  • Public fundingYes (hospital medicine, Classe H, since 05/2022)
    ≥2 failed antidepressants; AIFA monitoring registry
  • Worth knowingDelivery runs through regionally authorized psychiatric centers, availability varies by region.
  • WhereBari (4), Brindisi (2), Acquaviva delle Fonti, Altamura, Monopoli, Putignano, Andria, Barletta, Bisceglie, Foggia, Manfredonia, San Severo, Lecce, Casarano, Copertino, Galatina, Scorrano, Taranto
  • Access routespublic reimbursed (22)

Prices are published by providers themselves, no estimates. Full picture: the European Price Index and the reimbursement map.