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Gelre Ziekenhuizen

Apeldoorn / Zutphen, Netherlands

Treatment & access

About this provider

Gelre ziekenhuizen (Apeldoorn and Zutphen) offers esketamine nasal spray as a treatment for patients with difficult-to-treat depression, announced on its website on 9 April 2026. The treatment is used only when someone has tried at least three other medicines without sufficient result. Administration takes place in the hospital because side effects such as dizziness and sleepiness can occur; these usually subside after about an hour and a half. Patients receive the treatment in a specially equipped room where nurses are present to guide and monitor them. Gelre notes the medicine often works quickly, with some patients noticing improvement within a day. Appointments at the psychiatry outpatient clinic require a referral from a doctor, usually the general practitioner.

Services & programs

  • Esketamine nasal spray treatment for difficult-to-treat depression, administered in hospital in a specially equipped room with nurse guidance and monitoring
  • Outpatient, day-treatment and inpatient psychiatry (Medical Psychiatric Unit), including care for combined physical and psychological conditions
  • Mother-Baby Unit for mothers with a psychiatric condition (one of four hospitals in the Netherlands)

Common questions

Who qualifies for esketamine treatment at Gelre?

Patients with a difficult-to-treat depression who have tried at least three other medicines without sufficient result.

Do I need a referral?

Yes. You come to the psychiatry outpatient clinic by appointment after a referral from your doctor, usually the general practitioner.

What does the treatment look like?

The treatment takes place in the hospital in a specially equipped room where nurses guide and monitor you, because side effects such as dizziness and sleepiness can occur. These usually subside after about an hour and a half.

How quickly does it work?

Gelre states the medicine often works quickly; some patients notice improvement within a day.

Looking at alternatives? Esketamine nasal spray treatment is offered by specialised centres across the Netherlands affiliated with the national Esketamine Nasal Spray Consortium (ENC-NL), which lists Gelre ziekenhuizen among its affiliated institutions.

Verification

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